Anemia, diarrhea, and nausea are some of the most common side effects of capecitabine. However, most people tolerate the drug without problems. Serious side effects of capecitabine are uncommon, but if they occur, they should be reported immediately to your healthcare provider. A few of these side effects can include depression, an increase in tumor size, and signs of an allergic reaction. Some rare side effects of capecitabine can include things such as weight gain, stomach ulcers, and nosebleeds.

• Anemia -- in up to 80 percent of people (see Chemotherapy and Anemia)
• Hand-and-foot syndrome (redness and tenderness of the palms and soles) -- up to 60 percent
• Diarrhea -- up to 55 percent (see Chemotherapy-Induced Diarrhea)
• Nausea -- up to 53 percent (see Chemotherapy and Nausea)
• Fatigue or weakness -- up to 42 percent (see Chemotherapy and Fatigue)
• Vomiting -- up to 37 percent
• Abdominal pain (stomach pain) -- up to 35 percent
• Loss of appetite -- up to 26 percent
• Neutropenia (low levels of a certain type of white blood cell) -- up to 26 percent
• Mouth sores -- up to 25 percent (see Mouth and Gum Problems During Chemotherapy)
• Unusual sensations (such as burning or tingling) in the hands or feet -- up to 21 percent (see Nerve and Muscle Problems During Chemotherapy).
   

• Constipation (see Constipation With Chemotherapy)
• Eye irritation, vision changes, or conjunctivitis ("pink eye")
• Difficulty breathing
• Pain, including back pain, muscle pain, or joint pain (see Chemotherapy-Related Pain)
• Lethargy
• Headaches
• Indigestion or heartburn
• Dizziness
• Insomnia (see Xeloda and Insomnia)
• Dehydration
• Coughing
• Hair loss (see Xeloda and Hair Loss)
• Taste changes
• Mood changes.