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Eloxatin Dosage

Your healthcare provider will take into account your height and weight, your kidney function, and other factors when determining your specific dosage of Eloxatin. This medication is used in combination with leucovorin and 5-fluorouracil, and is given over a two-day period. This two-day treatment regimen is repeated every 14 days. For people with Stage III colon cancer, this regimen is usually continued for six months.

An Introduction to Your Dose of Eloxatin

The dose of Eloxatin® (oxaliplatin) your healthcare provider recommends will vary, depending on:
  • Your height and weight
  • How you tolerate the medication
  • Your kidney function.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Eloxatin Dosage

The standard dosage of Eloxatin for the treatment of colon and rectal cancer is based on body surface area, which is normally calculated using height and weight. Dosing that is based on body surface area is expressed as milligrams per meters squared, or mg per m2. The specific recommended dose of Eloxatin is 85 mg per m2, given every two weeks. The recommended dosage for people with severe kidney disease is Eloxatin 65 mg per m2.
Eloxatin is given in combination with two other chemotherapy medications: leucovorin and 5-fluorouracil (Adrucil®, Carac®, Efudex®, Fluoroplex®, also known as 5-FU). You will be given these medicines over two days, as follows:
  • Day 1: You will receive Eloxatin and leucovorin over a two-hour period. Immediately afterward, you will receive two doses of 5-fluorouracil -- the first one is given within minutes, while the second is given over 22 hours.
  • Day 2: You will be given leucovorin and 5-FU only, in the same way you received them on day one. However, you will not receive Eloxatin; it is only given on day one.
This two-day treatment regimen will be repeated in 14 days. The recommended length of treatment is six months in people with stage III colon cancer. People with advanced colorectal cancer will usually continue treatment until the cancer progresses or unacceptable side effects occur.
If you experience reactions during the Eloxatin infusion, your healthcare provider may recommend you receive your dose more slowly (for example, over six hours instead of two). Also, he or she may recommend a lower Eloxatin dosage for you if you experience certain serious side effects, such as nerve problems or low blood cell counts.
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