Colon Cancer Home > Zaltrap Drug Interactions

Although Zaltrap is not likely to interact with most drugs, combining it with clozapine may lead to problems. Using these medications together may increase your risk for extremely low white blood cell counts, which increases your risk for dangerous infections. Make sure your healthcare provider is aware of any products you are taking, as more interactions may be discovered in the future.

An Overview of Interactions With Zaltrap

Studies have not been done to determine if Zaltrap® (ziv-aflibercept) interacts with other medications. In general, it is not thought to react with most other products. However, Zaltrap may interact with clozapine (Clozaril®, FazaClo®).
 

Zaltrap Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Zaltrap is combined with any of the drugs listed above.
 
Clozapine
Using Zaltrap and clozapine together may increase the risk of dangerously low white blood cell counts and potentially serious infections. Talk to your healthcare provider before taking clozapine during Zaltrap treatment. However, do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
 
Chemotherapy Medicines
Zaltrap is normally given in combination with chemotherapy medicines, specifically leucovorin, 5-fluorouracil (Adrucil®, Carac®, Efudex®, Fluoroplex®, also known as 5-FU), and irinotecan (Camptosar®). Based on the available information, Zaltrap does not appear to interact with 5-fluorouracil or irinotecan.
 

Final Thoughts

Even though Zaltrap is currently believed to have very few, if any, potential drug interactions, it is important to understand that Zaltrap has not been systematically studied with other medications. Therefore, interactions may be discovered in the future.
 
Talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to you. Also, make sure your healthcare provider knows about all vitamins, herbal supplements, and prescription and nonprescription medications you are taking.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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