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Stivarga Side Effects

There have been extensive studies done to identify the side effects of Stivarga. This research showed that some of the most commonly reported problems include diarrhea, fatigue, and anemia. Because some reactions to this drug can be potentially dangerous, seek medical attention if you develop fever, unusual bleeding, or other serious problems.

An Introduction to Stivarga Side Effects

Just like any medicine, Stivarga® (regorafenib) can cause side effects. In fact, most people will experience some type of reaction to this drug, and some side effects can be quite significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
(This article covers many, but not all, of the possible side effects with Stivarga. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects With Stivarga

Stivarga has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people given Stivarga were carefully documented and compared to the side effects that occurred in a similar group of people given a placebo (a "sugar pill" that does not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
In clinical studies, the most common Stivarga side effects included:
Other common side effects, occurring in 1 percent to 29 percent of people, included but were not limited to:
  • Pain
  • Fever
  • Rash
  • Abnormal bleeding
  • Headache
  • Dry skin
  • An abnormal amount of protein in the urine, which could be a sign of kidney damage
  • Hair loss
  • Low levels of certain blood electrolytes, such as potassium, phosphate, calcium, sodium, and magnesium
  • Changes in taste
  • Increased liver enzymes, which could be a sign of liver damage
  • Muscle or bone stiffness
  • Dry mouth
  • A decrease in white blood cells, which could increase the risk for infection (see Chemotherapy and Infections)
  • An underactive thyroid (hypothyroidism)
  • An increase in amylase (a certain protein produced by the pancreas) in the blood
  • An abnormal international normalized ratio (INR), a test of how long it takes the blood to clot
  • Tremor
  • Heartburn or indigestion
  • An increase in uric acid in the blood
  • Symptoms of the stomach flu
  • Abnormal changes in fingernails or toenails.
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