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Vectibix Warnings and Precautions

You may develop potentially life-threatening skin reactions during treatment with Vectibix. People receiving this chemotherapy medication may also experience serious lung problems or infusion reactions with this drug. Other safety precautions with Vectibix involve understanding the warnings of potential drug interactions and an increased risk for eye problems. Also, women who are pregnant or breastfeeding should talk to their healthcare provider before beginning treatment.

What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to receiving Vectibix® (panitumumab) if you have:
  • Ever been told you have electrolyte abnormalities, such as low calcium or magnesium blood levels
  • Frequent sun exposure
  • Lung disease
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Breastfeeding
  • Pregnant or thinking of becoming pregnant.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Vectibix

Some warnings and precautions to be aware of prior to receiving this medication include the following:
  • Most people who receive Vectibix will experience a skin reaction during treatment. Skin reactions can include an acne-like or other type of rash or itchy, red, dry, cracking, or peeling skin. The reactions usually appear on the face, neck, or trunk, but can occur anywhere on the body, including around the eyes. Severe skin reactions can become infected, which could cause death.

In clinical trials, most reactions happened within the first two weeks of starting treatment and resolved within three months after the last Vectibix dose. Contact your healthcare provider immediately if you develop any skin reaction during treatment with this drug.

  • Sun exposure can increase the risk of developing Vectibix skin reactions. You should limit your time in the sun during treatment and for two months after your last dose. Be sure to wear protective clothing, such as a hat, and sunscreen when outside.
  • This medicine is only approved for use in people who have cancer that expresses a certain protein known as epidermal growth factor receptor (EGFR). Your healthcare provider will test you for EGFR before treatment.
  • There have been rare reports of serious lung disease occurring in people receiving Vectibix. Let your healthcare provider know if you develop any breathing problems, persistent cough, or wheezing during treatment. He or she may recommend you stop receiving Vectibix treatment.
  • Vectibix can cause an infusion reaction, which is a potentially life-threatening, allergic-type reaction that may occur during or shortly after receiving a dose. Your healthcare provider may choose to give you other medicines before your Vectibix dose to help prevent an infusion reaction. If you have an infusion reaction, your healthcare provider may slow down or stop your dose. Let your healthcare provider know immediately if you experience symptoms of an infusion reaction, which may include:
    • A skin rash or hives
    • Difficulty breathing
    • Shortness of breath
    • Fever
    • Chills.
  • You may develop low blood magnesium or calcium levels during treatment. Your healthcare provider will periodically monitor your magnesium and calcium levels, using a simple blood test, during treatment and for at least eight weeks after treatment ends. If your calcium or magnesium levels become too low, you may need oral or intravenous replacement to bring the levels back to normal.
  • This medication has been reported to cause potentially serious eye problems, including inflammation of the cornea (the front part of the eye). These eye problems can lead to serious complications that could cause loss of vision. Let your healthcare provider know if you have any signs of eye problems, such as:
    • Eye pain or redness
    • Excessive tearing
    • Blurred vision.
  • It is unknown if Vectibix passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to receiving the drug (see Vectibix and Breastfeeding).
  • Vectibix is a pregnancy Category C medication. This means it may not be safe for use during pregnancy, although the full risks are currently unknown (see Vectibix and Pregnancy).
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Vectibix Medication Information

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