Zaltrap Side Effects
Extensive studies have been done to identify possible side effects of Zaltrap. In these studies, the most commonly reported problems included diarrhea, a decrease in white blood cells, and an abnormal amount of protein in the urine. Because some reactions to this drug can be potentially dangerous, seek medical attention if you develop bloody stools, blurred vision, or other serious problems.
Just like any medicine, Zaltrap® (ziv-aflibercept) can cause side effects. In fact, most people will experience some type of reaction to this drug, and some side effects can be quite significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
(This article covers many, but not all, of the possible side effects with Zaltrap. Your healthcare provider can discuss a more complete list with you.)
Zaltrap has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people who received Zaltrap plus standard chemotherapy were carefully documented and compared to those that occurred in a similar group of people given a placebo (an injection that does not contain any active ingredients) plus standard chemotherapy.
As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo. In these studies, the most common Zaltrap side effects included:
- A decrease in white blood cells, which could increase the risk for infections (see Chemotherapy and Infections) -- in up to 78 percent of people
- Diarrhea (see Chemotherapy-Induced Diarrhea) -- up to 69 percent
- An abnormal amount of protein in the urine, which could be a sign of kidney damage -- up to 62 percent
- An increase in certain liver enzymes -- up to 62 percent
- Inflammation or ulcers in the mouth or throat (see Mouth and Gum Problems During Chemotherapy) -- up to 50 percent
- Fatigue -- up to 48 percent
- A decrease in platelets, which could increase the risk for bleeding (see Blood Clotting Problems and Chemotherapy) -- up to 48 percent
- Hypertension (high blood pressure) -- up to 41 percent
- Weight loss -- up to 32 percent
- Decreased appetite -- up to 32 percent
- Nosebleeds -- up to 28 percent
- Abdominal (stomach) pain -- up to 27 percent.
Other common reactions, occurring in 5 percent to 25 percent of people, included:
- Difficulty speaking, such as a hoarse voice
- An increase in serum creatinine, a measure of how well the kidneys are functioning
- Loss of strength and energy
- Shortness of breath
- Redness, swelling, or pain on the palms of the hands or soles of the feet
- Sore throat
- Darkening of the skin
- Runny nose
- Rectal pain.